Structure of a Plasmodium chabaudi acidic phosphoprotein that is associated with the host erythrocyte membrane.

Abstract

We have characterized by molecular cloning and sequencing a Plasmodium chabaudi antigen that is associated with the membrane of the infected erythrocyte throughout the entire intraerythrocytic cycle. The protein (PcEMA1) has a predicted size of 50 kDa and contains a major tandem repeat array of 16 octapeptides that constitutes almost 30% of the protein. At its amino-terminus, PcEMA1 has a string of hydrophobic residues characteristic of a secreted protein, but does not contain a hydrophobic membrane-spanning segment. The antigen appears to reside on the cytoplasmic face of the erythrocytic membrane. PcEMA1 has a predicted pI of 4.4 and is a potential phosphoprotein.

Statistics

0100200'00'02'04'06'08'10'12'14'16
Citations per Year

79 Citations

Semantic Scholar estimates that this publication has 79 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Deleersnijder1992StructureOA, title={Structure of a Plasmodium chabaudi acidic phosphoprotein that is associated with the host erythrocyte membrane.}, author={W Deleersnijder and P Prasomsitti and Sumalee Tungpradubkul and David R Hendrix and C{\'e}cile Hamers-Casterman and Raymond Hamers}, journal={Molecular and biochemical parasitology}, year={1992}, volume={56 1}, pages={59-68} }