Structure of a Pancreatic ATP-Sensitive Potassium Channel

Abstract

ATP-sensitive potassium channels (KATP) couple intracellular ATP levels with membrane excitability. These channels play crucial roles in many essential physiological processes and have been implicated extensively in a spectrum of metabolic diseases and disorders. To gain insight into the mechanism of KATP, we elucidated the structure of a hetero-octameric… (More)
DOI: 10.1016/j.cell.2016.12.028

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