Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.

  title={Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.},
  author={Hao Hu and Yang Liu and Mingzhu Wang and Junnan Fang and Hongda Huang and Na Yang and Yanbo Li and Jianyu Wang and Xuebiao Yao and Yunyu Shi and Guohong Li and Rui-Ming Xu},
  journal={Genes & development},
  volume={25 9},
In higher eukaryotes, the centromere is epigenetically specified by the histone H3 variant Centromere Protein-A (CENP-A). Deposition of CENP-A to the centromere requires histone chaperone HJURP (Holliday junction recognition protein). The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer. The C-terminal β-sheet domain of HJURP caps the DNA-binding region of the histone heterodimer, preventing it from spontaneous association with DNA. Our… CONTINUE READING
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