Structure of a BRCA1–BARD1 heterodimeric RING–RING complex

@article{Brzovic2001StructureOA,
  title={Structure of a BRCA1–BARD1 heterodimeric RING–RING complex},
  author={Peter S. Brzovic and Ponni Rajagopal and David W. Hoyt and Mary-Claire King and Rachel E. Klevit},
  journal={Nature Structural Biology},
  year={2001},
  volume={8},
  pages={833-837}
}
The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. [...] Key Result Comparison with the RING homodimer of the V(D)J recombination-activating protein RAG1 reveals the structural diversity of complexes formed by interactions between different RING domains. The BRCA1–BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple…Expand
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