Structure of WM bundles constituting the working memory system in early multiple sclerosis: A quantitative DTI tractography study

@article{Audoin2007StructureOW,
  title={Structure of WM bundles constituting the working memory system in early multiple sclerosis: A quantitative DTI tractography study},
  author={Bertrand Audoin and Maxime Guye and Françoise Reuter and My-Van Au Duong and Sylviane Confort-Gouny and Irina Malikova and Elisabeth Soulier and Patrick Viout and Andr{\'e} Ali Ch{\'e}rif and Patrick J. Cozzone and Jean Pelletier and Jean-Philippe Ranjeva},
  journal={NeuroImage},
  year={2007},
  volume={36},
  pages={1324-1330}
}
Working memory impairment is frequently observed in patients with early multiple sclerosis (MS). MRI and functional MRI studies have shown that working memory impairment is mostly due to diffuse white matter (WM) damage affecting the connectivity between distant cortical areas. However, working memory deficits in early MS patients can be either completely or partly masked by compensatory functional plasticity. It seems likely that concomitantly with the WM bundle injury resulting from… CONTINUE READING

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