Structure of Vitamin B12 : The Crystal Structure of the Hexacarboxylic Acid derived from B12 and the Molecular Structure of the Vitamin

@article{Hodgkin1955StructureOV,
  title={Structure of Vitamin B12 : The Crystal Structure of the Hexacarboxylic Acid derived from B12 and the Molecular Structure of the Vitamin},
  author={Dorothy Mary Crowfoot Hodgkin and Jenny Pickworth and John H. Robertson and Kenneth N. Trueblood and RICHARD J. Prosen and JOHN G. White},
  journal={Nature},
  year={1955},
  volume={176},
  pages={325-328}
}
Structure of Vitamin B12 : The Crystal Structure of the Hexacarboxylic Acid derived from B12 and the Molecular Structure of the Vitamin 
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173 Citations
Background Citations
14
Methods Citations
4

173 Citations

Some Observations on the Crystal Structure of a Chlorine-substituted Vitamin B12

Direct confirmation of the correctness of certain features of the outline structure of vitamin B121 in a rather interesting way is obtained.

The biosynthesis of adenosylcobalamin (vitamin B12).

This review provides the reader with a complete description of the transformation of uroporphyrinogen III into adenosylcobalamin (AdoCbl).

Microbial Production of Vitamin B12

From the chemical point of view, the term vitamin B12 is synonymous with cyanocobalamin, which is by far the most important component of the large family of the cobalt corrinoids. In this review,…

Vitamin B12 and the B12 coenzymes.

Porphyrin metabolism. IV. Molecular structure of acetamide derivatives affecting porphyrin metabolism.

THE BIOSYNTHESIS OF THE CORRIN STRUCTURE OF VITAMIN B12 *

To determine if the corrin moiety of the vitamin is indeed synthesized by a pathway similar to that of the porphyrins, &aminolevulinic acid-1,4-Ci4 was added to the medium of a growing culture of a streptomycete and found that the vitamin BIZ was indeed very radioactive.

Study of the reaction of formaldehyde with vitamin B12.

The Reduction of Vitamin B12

Two distinct reduction products of vitamin B12 have been described in the literature, by Diehl and Murie1 and by Boos, Carr and Conn2; we shall refer to these as I and II respectively. They differ in…

X-ray analysis and the structure of vitamin B12.

  • D. Hodgkin
  • Chemistry
    Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles
  • 1958
The structure of vitamin B12, as the authors think of it today, is based on a fascinating complex of evidence obtained by X-ray analysis and by more traditional chemical means, which has given a structure that fits in an extraordinarily reasonable way with such a variety of observations.

Microbial production of vitamin B12

The rich scientific history of vitamin B12 research, its biological functions and the pathways employed by bacteria for its de novo synthesis are described, and current strategies for the improvement ofitamin B12 production using modern biotechnological techniques are outlined.
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