Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes.

@article{Lowden2010StructureOV,
  title={Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes.},
  author={Michael J. Lowden and Karen Skorupski and Maria Guiseppina Pellegrini and Michael G Chiorazzo and Ronald K. Taylor and F Jon Kull},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 7},
  pages={2860-5}
}
Cholera is an acute intestinal infection caused by the bacterium Vibrio cholerae. In order for V. cholerae to cause disease, it must produce two virulence factors, the toxin-coregulated pilus (TCP) and cholera toxin (CT), whose expression is controlled by a transcriptional cascade culminating with the expression of the AraC-family regulator, ToxT. We have… CONTINUE READING