Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions

@article{Jiang2015StructureOT,
  title={Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions},
  author={Jiansen Jiang and Henry Chan and Darian D. Cash and Edward J. Miracco and Rachel R Ogorzalek Loo and Heather E. Upton and Duilio Cascio and Reid O’Brien Johnson and Kathleen Collins and Joseph A Loo and Z Hong Zhou and Juli Feigon},
  journal={Science},
  year={2015},
  volume={350}
}
Telomerase helps maintain telomeres by processive synthesis of telomere repeat DNA at their 3′-ends, using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT). We report the cryo–electron microscopy structure of Tetrahymena telomerase at ~9 angstrom resolution. In addition to seven known holoenzyme proteins, we identify two… CONTINUE READING