Structure of Small Viruses

@article{Crick1956StructureOS,
  title={Structure of Small Viruses},
  author={Francis H. C. Crick and James Dewey Watson},
  journal={Nature},
  year={1956},
  volume={177},
  pages={473-475}
}
Renewing their collaboration during Watson's return to the Cavendish laboratory in the fall of 1955, Watson and Crick in this article laid out a theory for explaining why all plant viruses whose structure had been studied up to that time were very similar in shape, either rod-shaped (cylindrical) or spherical. In developing their theory they once again benefited from their complementary expertise, namely Crick's extensive knowledge of X-ray crystallography and Watson's previous studies with… 
Structure of viruses: a short history
TLDR
This review is a partially personal account of the discovery of virus structure and its implication for virus function, covering all aspects of structural virology and to acknowledge relevant individuals.
The structure and assembly of simple viruses
TLDR
To study structure and function at the atomic level the authors must turn to the simpler viruses, which consist of a single strand of RNA enclosed in a protein coat, the symmetry of which provides a nice example of the expression of platonic form at the macromolecular level.
The basic architecture of viruses.
TLDR
Study of virus structures is required to understand structure-function relationships in viruses, including those related to morphogenesis and antigenicity, and these structural foundations can be extended to other macromolecular complexes that control many fundamental processes in biology.
Principles of Virus Structure
Structure-function relationships of icosahedral plant viruses
TLDR
X-ray diffraction studies on single crystals of a few viruses have led to the elucidation of their three dimensional structure at near atomic resolution, leading to a critical re-examination of the structural principles in the architecture of isometric viruses.
Quaternary and Tertiary Structures of Isometric RNA Viruses
TLDR
The current understanding of the relationship between the structures of simple RNA viruses and their function will be discussed using, as examples, three structures recently determined in the authors' laboratory, using two virus capsids and a tertiary structure from different virus subunits.
Viral Particles at Atomic Resolution
Crick and Watson (ref. 1) first recognized that spherical viruses had to be regular polyhedra. Of these, the icosahedron has the largest number (60) of asymmetric units and was subsequently found to
On the structure of viruses and their function as pathogens
TLDR
In the early 1930: s the biochemists invaded the field of virus research and Stanley was able to purify and crystallize the tobacco mosaic virus and to determine its chemical character, which formed the basis for a concept of viruses as giant nucleoprotein molecules.
The structure of small viruses.
...
...

References

SHOWING 1-10 OF 15 REFERENCES
An Infectious Nucleoprotein from Tobacco Mosaic Virus
TLDR
By reaggregation of these sub-units, a protein was obtained that had the same size and shape as the virus itself, but was not infectious1.
ELECTRON-MICROSCOPIC EVIDENCE FOR THE LOCALIZATION OF RIBONUCLEIC ACID IN THE PARTICLES OF TOBACCO MOSAIC VIRUS.
  • R. G. Hart
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1955
TLDR
The purpose of the present investigation was to obtain electron-microscopic evidence for or against the existence of such a structure in tobacco mosaic virus, and two kinds of evidence bearing on the location of the RNA in Tobacco mosaic virus have been found.
RECONSTITUTION OF ACTIVE TOBACCO MOSAIC VIRUS FROM ITS INACTIVE PROTEIN AND NUCLEIC ACID COMPONENTS.
and the unknoWns to all others. This gave consistently 0.0 lesions with the components used in virus reconstitution, except when the nucleic acid was applied at 200 jog./ml., twenty times the amount
CRYSTALLIZATION OF PURIFIED MEF-1 POLIOMYELITIS VIRUS PARTICLES.
TLDR
This is the first report of the crystallization of a virus affecting man or animals and the description of properties of three-dimensional crystals, readily visible in the light microscope, which were obtained from a highly purified and concentrated preparation of such virus particles.
Structure of the Crystals of Tomato Bushy Stunt Virus Preparations
WE have examined by X-ray methods crystals of the protein material prepared by F. C. Bawden and N. W. Pirie1 from tomato plants suffering from bushy stunt disease. The crystals were in the form of
Unit Cell Measurements of Wet and Dry Crystalline Turnip Yellow Mosaic Virus
TLDR
CBYSTALS of turnip yellow mosaic virus, kindly sent to us by Dr. Kenneth Smith and Dr. Roy Markham, were examined both optically and by X-ray diffraction to indicate that they were octahedral bipyramids.
Weight Relationships among Animal Viruses
TLDR
Electron microscopy, to which this safeguard cannot rigidly be applied, can undoubtedly provide excellent confirmatory evidence on particle size in the case of animal viruses.
Terminal Groups of Tobacco Mosaic Virus
TLDR
The first step towards a knowledge of the number and kind of these peptides would be the determination of the carboxylic and amino terminal groups.
...
...