Structure of Small Viruses

@article{Crick1956StructureOS,
  title={Structure of Small Viruses},
  author={F. Crick and J. Watson},
  journal={Nature},
  year={1956},
  volume={177},
  pages={473-475}
}
Renewing their collaboration during Watson's return to the Cavendish laboratory in the fall of 1955, Watson and Crick in this article laid out a theory for explaining why all plant viruses whose structure had been studied up to that time were very similar in shape, either rod-shaped (cylindrical) or spherical. In developing their theory they once again benefited from their complementary expertise, namely Crick's extensive knowledge of X-ray crystallography and Watson's previous studies with… Expand
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Principles of Virus Structure
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Quaternary and Tertiary Structures of Isometric RNA Viruses
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Viral Particles at Atomic Resolution
Crick and Watson (ref. 1) first recognized that spherical viruses had to be regular polyhedra. Of these, the icosahedron has the largest number (60) of asymmetric units and was subsequently found toExpand
On the structure of viruses and their function as pathogens
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In the early 1930: s the biochemists invaded the field of virus research and Stanley was able to purify and crystallize the tobacco mosaic virus and to determine its chemical character, which formed the basis for a concept of viruses as giant nucleoprotein molecules. Expand
Physical Principles in the Self-Assembly of a Simple Spherical Virus.
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References

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An Infectious Nucleoprotein from Tobacco Mosaic Virus
TLDR
By reaggregation of these sub-units, a protein was obtained that had the same size and shape as the virus itself, but was not infectious1. Expand
CRYSTALLIZATION OF PURIFIED MEF-1 POLIOMYELITIS VIRUS PARTICLES.
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  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
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TLDR
This is the first report of the crystallization of a virus affecting man or animals and the description of properties of three-dimensional crystals, readily visible in the light microscope, which were obtained from a highly purified and concentrated preparation of such virus particles. Expand
Structure of the Crystals of Tomato Bushy Stunt Virus Preparations
WE have examined by X-ray methods crystals of the protein material prepared by F. C. Bawden and N. W. Pirie1 from tomato plants suffering from bushy stunt disease. The crystals were in the form ofExpand
The structure of tobacco mosaic virus. I. X-ray evidence of a helical arrangement of sub-units around the longitudinal axis.
  • J. Watson
  • Biology, Medicine
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TLDR
It is suggested that the virus contains a large number of equivalent sub-units helically arranged about the longitudinal axis and that n is of the order of 10; thus the molecular weight of a sub-unit is approximately 35,000 and the number within an infective particle is approximately 1,200. Expand
Unit Cell Measurements of Wet and Dry Crystalline Turnip Yellow Mosaic Virus
TLDR
CBYSTALS of turnip yellow mosaic virus, kindly sent to us by Dr. Kenneth Smith and Dr. Roy Markham, were examined both optically and by X-ray diffraction to indicate that they were octahedral bipyramids. Expand
RECONSTITUTION OF ACTIVE TOBACCO MOSAIC VIRUS FROM ITS INACTIVE PROTEIN AND NUCLEIC ACID COMPONENTS.
Weight Relationships among Animal Viruses
TLDR
Electron microscopy, to which this safeguard cannot rigidly be applied, can undoubtedly provide excellent confirmatory evidence on particle size in the case of animal viruses. Expand
On Growth and Form
TLDR
This book is an application of some of the concepts of physical science and sundry mathematical methods to the study of organic form and is like one of Darwin's books, well-considered, patiently wrought-out, learned, and cautious. Expand
Terminal Groups of Tobacco Mosaic Virus
TLDR
The first step towards a knowledge of the number and kind of these peptides would be the determination of the carboxylic and amino terminal groups. Expand
C-terminal amino-acid sequence of tobacco mosaic virus protein.
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