Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.

@article{Li2005StructureOS,
  title={Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.},
  author={Fang Li and Wenhui Li and Michael Farzan and Stephen C. Harrison},
  journal={Science},
  year={2005},
  volume={309 5742},
  pages={
          1864-8
        }
}
  • Fang Li, Wenhui Li, +1 author Stephen C. Harrison
  • Published in Science 2005
  • Medicine, Biology
  • The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the… CONTINUE READING

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    Materials and methods are available as supporting materials on Science Online

    Single-letter abbreviations for the amino acid residues are as follows: A, Ala

    • Cys D Asp, E Glu, +6 authors M Met

    We thank members of the Lin and Sinclair labs for References and Notes