Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor

@article{Li2005StructureOS,
  title={Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor},
  author={Fang Li and W. Li and M. Farzan and S. Harrison},
  journal={Science},
  year={2005},
  volume={309},
  pages={1864 - 1868}
}
The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the… Expand
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References

SHOWING 1-10 OF 73 REFERENCES
Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine
  • Y. He, Y. Zhou, +4 authors S. Jiang
  • Medicine, Chemistry
  • Biochemical and Biophysical Research Communications
  • 2004
  • 268
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
  • 664
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
  • 3,430
  • PDF
Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion protein
  • 109
  • PDF
Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association.
  • J. Sui, W. Li, +11 authors W. Marasco
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
  • 507
  • PDF
The Genome Sequence of the SARS-Associated Coronavirus
  • 1,795
  • PDF
...
1
2
3
4
5
...