Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor

  title={Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor},
  author={Fang Li and W. Li and M. Farzan and S. Harrison},
  pages={1864 - 1868}
  • Fang Li, W. Li, +1 author S. Harrison
  • Published 2005
  • Biology, Medicine
  • Science
  • The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the… CONTINUE READING
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