Structure of RapA, a Swi2/Snf2 protein that recycles RNA polymerase during transcription.

@article{Shaw2008StructureOR,
  title={Structure of RapA, a Swi2/Snf2 protein that recycles RNA polymerase during transcription.},
  author={Gary X Shaw and Jianhua Gan and Yan Ning Zhou and Huijun Zhi and Priadarsini Subburaman and Rongguang Zhang and Andrzej Joachimiak and Ding Jun Jin and Xinhua Ji},
  journal={Structure},
  year={2008},
  volume={16 9},
  pages={
          1417-27
        }
}
RapA, as abundant as sigma70 in the cell, is an RNA polymerase (RNAP)-associated Swi2/Snf2 protein with ATPase activity. It stimulates RNAP recycling during transcription. We report a structure of RapA that is also a full-length structure for the entire Swi2/Snf2 family. RapA contains seven domains, two of which exhibit novel protein folds. Our model of RapA in complex with ATP and double-stranded DNA (dsDNA) suggests that RapA may bind to and translocate on dsDNA. Our kinetic template… CONTINUE READING

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Structural basis for transcription reactivation by RapA.

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