Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.

Abstract

RPE65 is a key metalloenzyme responsible for maintaining visual function in vertebrates. Despite extensive research on this membrane-bound retinoid isomerase, fundamental questions regarding its enzymology remain unanswered. Here, we report the crystal structure of RPE65 in a membrane-like environment. These crystals, obtained from enzymatically active… (More)
DOI: 10.1073/pnas.1212025109

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