Structure of Papain

  title={Structure of Papain},
  author={Jan Drenth and Johan N. Jansonius and Roelof Koekoek and H. M. Swen and Bert G. Wolthers},
A three-dimensional X-ray study at a resolution of 2.8 Å has revealed that the single polypeptide chain of 211 residues is folded into two distinct parts which are divided by a cleft. The active site, consisting of a cysteine and a histidine, lies at the surface of the cleft. Apart from four short α-helical segments and one short segment of β-structure, the conformation of the chain is irregular. 

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  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 1967
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