Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75

@article{He2004StructureON,
  title={Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75},
  author={Xiao-lin He and K. Christopher Garcia},
  journal={Science},
  year={2004},
  volume={304},
  pages={870 - 875}
}
Neurotrophins are secreted growth factors critical for the development and maintenance of the vertebrate nervous system. Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 Å crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75. Surprisingly, the complex is composed of an NGF homodimer asymmetrically bound to a… 
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The 2.6-Å resolution crystal structure of neurotrophin-3 (NT-3) complexed to the ectodomain of glycosylated p75NTR is reported to provide a model for NTs-p75N TR recognition and signal generation, as well as insights into coordination between p 75NTR and Trks.
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