Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75

  title={Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75},
  author={Xiao-lin He and K. Christopher Garcia},
  pages={870 - 875}
Neurotrophins are secreted growth factors critical for the development and maintenance of the vertebrate nervous system. Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor. We have determined the 2.4 Å crystal structure of the prototypic neurotrophin, nerve growth factor (NGF), complexed with the extracellular domain of p75. Surprisingly, the complex is composed of an NGF homodimer asymmetrically bound to a… 
Characterization of Symmetric Complexes of Nerve Growth Factor and the Ectodomain of the Pan-neurotrophin Receptor, p75NTR*
Following assembly and purification of soluble p75NTR·NGF complexes, mass spectrometry, analytical ultracentrifugation, and solution x-ray scattering measurements are indicative of 2:2 stoichiometry, which implies a symmetric complex.
Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex
The 2.6-Å resolution crystal structure of neurotrophin-3 (NT-3) complexed to the ectodomain of glycosylated p75NTR is reported to provide a model for NTs-p75N TR recognition and signal generation, as well as insights into coordination between p 75NTR and Trks.
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Neurotrophin availability is required into adulthood, where they control synaptic function and plasticity and sustain neuronal cell survival, morphology, and differentiation.
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This review will update the neurotrophin signaling pathways known for Trk receptors to include newly identified Trk-interacting molecules and will address surprising new findings that suggest a role for p75NTR in different receptor complexes and functions.
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expression of NGF and its receptors is localized in ovarian cells from several species, which suggests that NGFand its receptors may regulate some ovarian functions such as follicular survival or development, which may be of critical importance for researchers who want to promote follicular development in vitro in the future.
Neurotrophins and Their Receptors
A small family of growth factors known as neurotrophins regulates many different aspects of neuronal function and is best known for their ability to promote the survival of embryonic neurons and to promote growth of neuronal axons.


Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
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It is reported here that, in contrast to other proapoptotic receptors such as Fas, apoptosis induction by p75NTR requires monomerization, with dimerization inhibiting the effect.