Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation.

@article{Chang2003StructureOM,
  title={Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation.},
  author={Geoffrey Chang},
  journal={Journal of molecular biology},
  year={2003},
  volume={330 2},
  pages={
          419-30
        }
}
The spread of multidrug resistance (MDR) is a world health crisis that presents a significant challenge to the treatment of cancer and infection. MDR can be caused by a group of ABC (MDR-ABC) transporters that move hydrophobic drug molecules and lipids across the cell membrane. To gain insight into the conformational changes these transporters undergo when flipping hydrophobic substrates across the lipid bilayer, we have determined the structure of the lipid flippase MsbA from Vibrio cholera… CONTINUE READING

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