Structure of Leishmania lipophosphoglycan: inter- and intra-specific polymorphism in Old World species.

  title={Structure of Leishmania lipophosphoglycan: inter- and intra-specific polymorphism in Old World species.},
  author={Malcolm J. McConville and Lionel F. Schnur and Charles L. Jaffe and Pascal Schneider},
  journal={The Biochemical journal},
  volume={310 ( Pt 3)},
The most abundant surface macromolecule on the promastigote stage of leishmanial parasites is a polymorphic lipophosphoglycan (LPG). We have elucidated the structures of two new LPGs, from Leishmania tropica (LRC-L36) and L. aethiopica (LRC-L495), and investigated the nature of intra-specific polymorphism in the previously characterized LPG of L. major (LRC-L456 and -L580). These molecules contain a phosphoglycan chain, made up of repeating PO4-6Gal beta 1-4Man units and a conserved… 

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