Structure of L-A Virus: A Specialized Compartment for the Transcription and Replication of Double-stranded RNA

@article{Castn1997StructureOL,
  title={Structure of L-A Virus: A Specialized Compartment for the Transcription and Replication of Double-stranded RNA },
  author={Jos{\'e} R Cast{\'o}n and Benes L. Trus and Frank P. Booy and Reed B Wickner and Joseph S. Wall and Alasdair C. Steven},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={138},
  pages={975 - 985}
}
The genomes of double-stranded (ds)RNA viruses are never exposed to the cytoplasm but are confined to and replicated from a specialized protein-bound compartment-the viral capsid. We have used cryoelectron microscopy and three-dimensional image reconstruction to study this compartment in the case of L-A, a yeast virus whose capsid consists of 60 asymmetric… CONTINUE READING
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