Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization

@article{Ohto2016StructureOI,
  title={Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization},
  author={U. Ohto and H. Ishida and Elena Krayukhina and S. Uchiyama and N. Inoue and T. Shimizu},
  journal={Nature},
  year={2016},
  volume={534},
  pages={566-569}
}
Fertilization is a fundamental process in sexual reproduction, creating a new individual through the combination of male and female gametes. The IZUMO1 sperm membrane protein and its counterpart oocyte receptor JUNO have been identified as essential factors for sperm–oocyte interaction and fusion. However, the mechanism underlying their specific recognition remains poorly defined. Here, we show the crystal structures of human IZUMO1, JUNO and the IZUMO1–JUNO complex, establishing the structural… Expand
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