Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer.

@article{Escalante2007StructureOI,
  title={Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer.},
  author={Carlos Escalante and Estanislao Nistal-Villan and Leyi Shen and Adolfo Garc{\'i}a-Sastre and Aneel K. Aggarwal},
  journal={Molecular cell},
  year={2007},
  volume={26 5},
  pages={
          703-16
        }
}
Interferon regulatory factor 3 (IRF-3) is a key transcription factor in the assembly of the mammalian interferon-beta (IFN-beta) enhanceosome. We present here the structure of IRF-3 DNA binding domain in complex with the complete PRDIII-I regulatory element of the human IFN-beta enhancer. We show that four IRF-3 molecules bind in tandem to, variably spaced, consensus and nonconsensus IRF sites on the composite element. The ability of IRF-3 to bind these variable sites derives in part from two… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS

Similar Papers

Loading similar papers…