Structure of Human DROSHA

  title={Structure of Human DROSHA},
  author={Sarah C Kwon and Tuan Anh Nguyen and Yeon-Gil Choi and Myung Hyun Jo and Sungchul Hohng and V. Narry Kim and J Woo},
MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA. DROSHA functions together with its cofactor DGCR8 in a heterotrimeric complex known as Microprocessor. Here, we report the X-ray structure of DROSHA in complex with the C-terminal helix of DGCR8. We find that DROSHA contains two DGCR8-binding sites, one on each RNase III domain (RIIID), which mediate the assembly of Microprocessor. The overall structure of DROSHA is surprisingly similar to that… CONTINUE READING
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TheMicroprocessor complexmediates the genesis of microRNAs

  • R. I. Gregory, Yan, +5 authors R. Shiekhattar
  • Nature 432, 235–240.
  • 2004
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