Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

@article{Rehmann2008StructureOE,
  title={Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B},
  author={H. Rehmann and E. Arias-Palomo and M. Hadders and F. Schwede and O. Llorca and J. Bos},
  journal={Nature},
  year={2008},
  volume={455},
  pages={124-127}
}
Epac proteins are activated by binding of the second messenger cAMP and then act as guanine nucleotide exchange factors for Rap proteins. The Epac proteins are involved in the regulation of cell adhesion and insulin secretion. Here we have determined the structure of Epac2 in complex with a cAMP analogue (Sp-cAMPS) and RAP1B by X-ray crystallography and single particle electron microscopy. The structure represents the cAMP activated state of the Epac2 protein with the RAP1B protein trapped in… Expand
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