Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold.

  title={Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold.},
  author={Ralph Kraetzner and Judit E Debreczeni and Thomas Pape and Thomas R. Schneider and Alexander Wentzel and Harald Kolmar and George M. Sheldrick and Isabel Us{\'o}n},
  journal={Acta crystallographica. Section D, Biological crystallography},
  volume={61 Pt 9},
The Ecballium elaterium trypsin inhibitor II (EETI-II) belongs to the family of squash inhibitors and is one of the strongest inhibitors known for trypsin. The eight independent molecules of EETI-II in the crystal structure reported here provide a good opportunity to test the hypothesis that this small cystine-knot protein (knottin) is sufficiently rigid to be used as a molecular scaffold for protein-engineering purposes. To extend this test, the structures of two complexes of EETI-II with… CONTINUE READING
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