Structure of DnmZ, a nitrososynthase in the Streptomyces peucetius anthracycline biosynthetic pathway.

@article{Sartor2015StructureOD,
  title={Structure of DnmZ, a nitrososynthase in the Streptomyces peucetius anthracycline biosynthetic pathway.},
  author={Lauren Sartor and Charmaine Ibarra and Ahmad Al-Mestarihi and Brian O. Bachmann and Jessica Lynn Vey},
  journal={Acta crystallographica. Section F, Structural biology communications},
  year={2015},
  volume={71 Pt 10},
  pages={1205-14}
}
The anthracyclines are a class of highly effective natural product chemotherapeutics and are used to treat a range of cancers, including leukemia. The toxicity of the anthracyclines has stimulated efforts to further diversify the scaffold of the natural product, which has led to renewed interest in the biosynthetic pathway responsible for the formation and modification of this family of molecules. DnmZ is an N-hydroxylating flavin monooxygenase (a nitrososynthase) that catalyzes the oxidation… CONTINUE READING
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