Structure of Dicer and mechanistic implications for RNAi.


Dicer is a specialized ribonuclease that processes double-stranded RNA (dsRNA) into small RNA fragments about 25 nucleotides in length during the initiation phase of RNA interference (RNAi). We previously determined the crystal structure of a Dicer enzyme from the diplomonad Giardia intestinalis and proposed a structural model for dsRNA processing. Here, we… (More)


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@article{MacRae2006StructureOD, title={Structure of Dicer and mechanistic implications for RNAi.}, author={Ian J MacRae and F. Li and Kai Zhou and W. Zacheus Cande and Johannes Doudna}, journal={Cold Spring Harbor symposia on quantitative biology}, year={2006}, volume={71}, pages={73-80} }