Structure of Collagen

  title={Structure of Collagen},
  author={G. N. Ramachandran and Gopinath Kartha},
A DETAILED X-ray study of collagen fibres obtained from different sources (namely, shark ray, rat tail tendon and kangaroo tail tendon) and a re-examination of the published wide-angle patterns indicate that the unit cell of collagen is hexagonal with a = 12–16 A. and c = 9.5–9 A., the actual values depending on the moisture content. The essential difference of this indexing from those reported earlier1–3 is that the 2.86-A. meridional arc is here interpreted not as a true meridional reflexion… 
Numerical modeling of the effects hydration and number of hydrogen bonds on the mechanical properties of the tropocollagen molecule
A novel three-dimensional finite element model of collagen molecule accounting for hydrogen bonds was developed and it was demonstrated that the mechanical properties of tropocollagen are slightly affected by the rate of hydration but considerably affected by variation of the number of hydrogen bonds.
Linking structural and compositional changes in archaeological human bone collagen: an FTIR-ATR approach
FTIR-ATR spectroscopy is suggested to be an ideal technique for collagen characterization/pre-screening for palaeodiet, mobility and radiocarbon research.
7/2-Helical model for collagen — Evidence from model peptides
The comparison of water molecules found in these structures, together with the water bridges involving the hydroxyl group of Hyp, indicated that water molecules do not contribute to the extra stability of the triple-helix as has been considered for many years.
Collagen, a common thread in extracellular matrix evolution
  • R. Garrone
  • Biology
    Proceedings / Indian Academy of Sciences
  • 1999
The comparisons of collagen in lower animals suggest similarities with several collagen types of vertebrates, and it could be suggested that some of the non-fibrillar collagen types are involved in tissue micro- or macro-specialization in vertebrates.
Regulation of procollagen genes. From forces to factors
The existence of multiple mediators regulating collagen deposition provides important questions and challenges for the future, and techniques of molecular genetics are being applied to the above diseases and should be instructive in the identification of key mediators in disease.
Mechanism of collagen folding propagation studied by Molecular Dynamics simulations
The triple helix folding was found to propagate involving first two chains forming a short transient template and three residues of the third chain fold on this template with an overall mean propagation of ~75 ns per unit.
The Madras Group and the structure of collagen
The genesis of the collagen structure proposed by the Madras Group is briefly outlined. Recent crystal structure data on collagen-like peptides vindicate (i) the original proposal of Ramachandran and
Principles and development of collagen-mediated tissue fusion induced by laser irradiation
Low-temperature laser-mediated tissue fusion causes collagen fibril bundles to loosen and swell, and crimping causes the fibres to intertwine, and this technology could be applied to fuse tissues during surgery.