Structure of Colchicine

  title={Structure of Colchicine},
  author={M. Dewar},
  • M. Dewar
  • Published 1945
  • Chemistry
  • Nature
  • IN view of the remarkable physiological properties of colchicine its chemical nature is of some interest. Until recently, the structure (I) proposed by Windaus1 has been generally accepted, although the stability of colchicine did not suggest a 9-amino-9: 10-di-hydrophenanthrene system, and although the salicylaldehyde enol structure of ring C appeared fantastic. Cohen, Cook and Roe2 have now provided evidence that ring B must be 7-membered, but the exact location of the acetamido group remains… CONTINUE READING
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