Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli.

@article{Li2009StructureOC,
  title={Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli.},
  author={Yong-Fu Li and Steven Thomas Poole and Kazuya Nishio and Ken Jang and Fatima Rasulova and Annette L. McVeigh and Stephen J. Savarino and Di Xia and Esther Bullitt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 26},
  pages={
          10793-8
        }
}
Adhesion pili (fimbriae) play a critical role in initiating the events that lead to intestinal colonization and diarrheal disease by enterotoxigenic Escherichia coli (ETEC), an E. coli pathotype that inflicts an enormous global disease burden. We elucidate atomic structures of an ETEC major pilin subunit, CfaB, from colonization factor antigen I (CFA/I) fimbriae. These data are used to construct models for 2 morphological forms of CFA/I fimbriae that are both observed in vivo: the helical… CONTINUE READING

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