Structure of Botulinum Neurotoxin Channels in Phospholipid Vesicles

  title={Structure of Botulinum Neurotoxin Channels in Phospholipid Vesicles},
  author={Michael F. Schmid and Jeffrey Paul Robinson and Bibhuti R. Dasgupta},
Botulinum neurotoxins comprise a class of potent inhibitors of neurotransmitter release, thus acting presynaptically. Their function has been biochemically dissected into distinct stages: i) cell surface attachment; ii) internalization via the endocytotic/lysosomal vesicle pathway; iii) penetration into the cytoplasm from these vesicles through a pH-dependent conformational change; and iv) intracellular poisoning.1 There are seven distinct serotypes, some of which have been sequenced.2