Structure of Actin-related protein 8 and its contribution to nucleosome binding

@inproceedings{Gerhold2012StructureOA,
  title={Structure of Actin-related protein 8 and its contribution to nucleosome binding},
  author={Christian B. Gerhold and Duane David Winkler and Kristina Lakomek and Florian Ulrich Seifert and Sebastian Fenn and Brigitte Kessler and Gregor Witte and Karolin Luger and Karl-Peter Hopfner},
  booktitle={Nucleic acids research},
  year={2012}
}
Nuclear actin-related proteins (Arps) are subunits of several chromatin remodelers, but their molecular functions within these complexes are unclear. We report the crystal structure of the INO80 complex subunit Arp8 in its ATP-bound form. Human Arp8 has several insertions in the conserved actin fold that explain its inability to polymerize. Most remarkably, one insertion wraps over the active site cleft and appears to rigidify the domain architecture, while active site features shared with… CONTINUE READING

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