Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

  title={Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle},
  author={K. Verschueren and C. Blanchet and J. Felix and Ann Dansercoer and D. D. De Vos and Y. Bloch and J. V. van Beeumen and D. Svergun and I. Gutsche and S. Savvides and K. Verstraete},
  • K. Verschueren, C. Blanchet, +8 authors K. Verstraete
  • Published 2019
  • Medicine
  • Nature
  • Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1. The latter fuels pivotal biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine2, and the acetylation of histones and proteins3,4. In autotrophic prokaryotes, ACLY is a hallmark enzyme of the… CONTINUE READING
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