Structure of α6β3δ GABAA receptors and their lack of ethanol sensitivity

  title={Structure of α6β3δ GABAA receptors and their lack of ethanol sensitivity},
  author={R. Baur and Kuldeep H. Kaur and E. Sigel},
  journal={Journal of Neurochemistry},
  • R. Baur, Kuldeep H. Kaur, E. Sigel
  • Published 2009
  • Biology, Medicine
  • Journal of Neurochemistry
  • Delta (δ) subunit containing GABAA receptors are expressed extra‐synaptically and mediate tonic inhibition. In cerebellar granule cells, they often form a receptor together with α6 subunits. We were interested to determine the architecture of these receptors. We predefined the subunit arrangement of 24 different GABAA receptor pentamers by subunit concatenation. These receptors (composed of α6, β3 and δ subunits) were expressed in Xenopus oocytes and their electrophysiological properties… CONTINUE READING
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