Structure of α6β3δ GABAA receptors and their lack of ethanol sensitivity

@article{Baur2009StructureO,
  title={Structure of $\alpha$6$\beta$3$\delta$ GABAA receptors and their lack of ethanol sensitivity},
  author={Roland Baur and Kuldeep H Kaur and Erwin Sigel},
  journal={Journal of Neurochemistry},
  year={2009},
  volume={111}
}
Delta (δ) subunit containing GABAA receptors are expressed extra‐synaptically and mediate tonic inhibition. In cerebellar granule cells, they often form a receptor together with α6 subunits. We were interested to determine the architecture of these receptors. We predefined the subunit arrangement of 24 different GABAA receptor pentamers by subunit concatenation. These receptors (composed of α6, β3 and δ subunits) were expressed in Xenopus oocytes and their electrophysiological properties… 
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TLDR
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The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol
TLDR
Ethanol at 30 mM did not affect tonic GABA-mediated currents in dentate gyrus reported to be mediated by GABAARs incorporating α4 and δ subunits, suggesting that as yet unidentified factors may play a critical role in the ethanol effects on δ-containing GABA ARs.
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TLDR
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TLDR
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TLDR
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TLDR
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