Structure of α6β3δ GABAA receptors and their lack of ethanol sensitivity

@article{Baur2009StructureO,
  title={Structure of α6β3δ GABAA receptors and their lack of ethanol sensitivity},
  author={R. Baur and Kuldeep H. Kaur and E. Sigel},
  journal={Journal of Neurochemistry},
  year={2009},
  volume={111}
}
  • R. Baur, Kuldeep H. Kaur, E. Sigel
  • Published 2009
  • Biology, Medicine
  • Journal of Neurochemistry
    • Delta (δ) subunit containing GABAA receptors are expressed extra‐synaptically and mediate tonic inhibition. In cerebellar granule cells, they often form a receptor together with α6 subunits. We were interested to determine the architecture of these receptors. We predefined the subunit arrangement of 24 different GABAA receptor pentamers by subunit concatenation. These receptors (composed of α6, β3 and δ subunits) were expressed in Xenopus oocytes and their electrophysiological properties… CONTINUE READING
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    References

    SHOWING 1-10 OF 46 REFERENCES
    Unanticipated Structural and Functional Properties of δ-Subunit-containing GABAA Receptors*
    • 70
    • PDF
    The δ Subunit of γ-Aminobutyric Acid Type A Receptors Does Not Confer Sensitivity to Low Concentrations of Ethanol
    • 157
    • PDF
    Rat α6β2δ GABAA receptors exhibit two distinct and separable agonist affinities
    • 54
    The α1 and α6 Subunits Can Coexist in the Same Cerebellar GABAA Receptor Maintaining Their Individual Benzodiazepine‐Binding Specificities
    • 84
    A new naturally occurring GABAA receptor subunit partnership with high sensitivity to ethanol
    • 234
    • PDF
    Ligand-Gated Ion Channel Subunit Partnerships: GABAAReceptor α6 Subunit Gene Inactivation Inhibits δ Subunit Expression
    • 312
    • PDF
    Subunit Arrangement of γ-Aminobutyric Acid Type A Receptors*
    • 213
    • PDF
    Subunit Composition and Quantitative Importance of Hetero-oligomeric Receptors: GABAA Receptors Containing α6 Subunits
    • 200
    • PDF
    Positioning of the α-subunit isoforms confers a functional signature to γ-aminobutyric acid type A receptors
    • 102
    • PDF
    Ethanol enhances α4β3δ and α6β3δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans
    • 398
    • PDF