Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.

@article{Poeta1998StructureinVA,
  title={Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.},
  author={Maurizio del Poeta and Wiley A. Schell and Christine C. Dykstra and Susan Kilgore Jones and Richard R. Tidwell and Anna Czarny and Miroslav Baji{\'c} and Arvind Kumar and David W Boykin and John R Perfect},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 10},
  pages={2495-502}
}
Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic substituted bis-benzimidazoles were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. A majority of the compounds had MICs at which 80% of the strains were inhibited (MIC80s) comparable to those of amphotericin B and fluconazole. Unlike fluconazole, many of these compounds were found to have potent fungicidal activity. The most potent compound… CONTINUE READING