Structure-function studies on recombinant human macrophage colony-stimulating factor (M-CSF).

@article{Taylor1994StructurefunctionSO,
  title={Structure-function studies on recombinant human macrophage colony-stimulating factor (M-CSF).},
  author={Eric W. Taylor and A L Fear and Andrew Bohm and Sung Ho Kim and Kirston Koths},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 49},
  pages={31171-7}
}
Human macrophage colony-stimulating factor (M-CSF) is a homodimeric cytokine that is a member of a structurally related family of hormones defined by an unusual up-up-down-down alpha-helical bundle. To identify regions on the surface of M-CSF that might interact with the M-CSF receptor, single and double amino acid substitutions were introduced into a… CONTINUE READING