Structure function studies of vaccinia virus host range protein k1 reveal a novel functional surface for ankyrin repeat proteins.

@article{Li2010StructureFS,
  title={Structure function studies of vaccinia virus host range protein k1 reveal a novel functional surface for ankyrin repeat proteins.},
  author={Yongchao Li and Xiangzhi Meng and Yan Xiang and Junpeng Deng},
  journal={Journal of virology},
  year={2010},
  volume={84 7},
  pages={3331-8}
}
Poxvirus host tropism at the cellular level is regulated by virus-encoded host range proteins acting downstream of virus entry. The functioning mechanisms of most host range proteins are unclear, but many contain multiple ankyrin (ANK) repeats, a motif that is known for ligand interaction through a concave surface. We report here the crystal structure of one of the ANK repeat-containing host range proteins, the vaccinia virus K1 protein. The structure, at a resolution of 2.3 A, showed that K1… CONTINUE READING