Structure-function studies of chemokine-derived carboxy-terminal antimicrobial peptides.

  title={Structure-function studies of chemokine-derived carboxy-terminal antimicrobial peptides.},
  author={Leonard Tu Nguyen and David I Chan and Laura Boszhard and Sebastiaan A J Zaat and Hans J. Vogel},
  journal={Biochimica et biophysica acta},
  volume={1798 6},
Recent reports which show that several chemokines can act as direct microbicidal agents have drawn renewed attention to these chemotactic signalling proteins. Here we present a structure-function analysis of peptides derived from the human chemokines macrophage inflammatory protein-3alpha (MIP-3alpha/CCL20), interleukin-8 (IL-8), neutrophil activating protein-2 (NAP-2) and thrombocidin-1 (TC-1). These peptides encompass the C-terminal alpha-helices of these chemokines, which have been suggested… CONTINUE READING

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