Structure-function relationships of the G domain, a canonical switch motif.

@article{Wittinghofer2011StructurefunctionRO,
  title={Structure-function relationships of the G domain, a canonical switch motif.},
  author={Alfred Wittinghofer and Ingrid R. Vetter},
  journal={Annual review of biochemistry},
  year={2011},
  volume={80},
  pages={943-71}
}
GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The common principle is the 160-180-residue G domain with an α,β topology that is responsible for nucleotide-dependent conformational changes and drives many biological functions. Although the G domain uses a universally conserved switching mechanism, its structure, function, and GTPase reaction are modified for many… CONTINUE READING
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