Structure-function relationships of shared-stem and conventional molecular beacons.

  title={Structure-function relationships of shared-stem and conventional molecular beacons.},
  author={Andrew Tsourkas and Mark A Behlke and Gang Bao},
  journal={Nucleic acids research},
  volume={30 19},
Molecular beacons are oligonucleotide probes capable of forming a stem-loop hairpin structure with a reporter dye at one end and a quencher at the other end. Conventional molecular beacons are designed with a target-binding domain flanked by two complementary short arm sequences that are independent of the target sequence. Here we report the design of shared-stem molecular beacons with one arm participating in both stem formation when the beacon is closed and target hybridization when it is… CONTINUE READING

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