Structure-function relationship of human neutrophil collagenase: identification of regions responsible for substrate specificity and general proteinase activity.

@article{Hirose1993StructurefunctionRO,
  title={Structure-function relationship of human neutrophil collagenase: identification of regions responsible for substrate specificity and general proteinase activity.},
  author={Toshiharu Hirose and C. G. Patterson and Tayebeh Pourmotabbed and Carlo L. Mainardi and Karen A. Hasty},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 7},
  pages={2569-73}
}
The family of matrix metalloproteinases is a family of closely related enzymes that play an important role in physiological and pathological processes of matrix degradation. The most distinctive characteristic of interstitial collagenases (fibroblast and neutrophil collagenases) is their ability to cleave interstitial collagens at a single peptide bond; however, the precise region of the enzyme responsible for this substrate specificity remains to be defined. To address this question, we… CONTINUE READING