Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.

@article{Chapple1998StructurefunctionRO,
  title={Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111.},
  author={Daniel S Chapple and Douglas J. Mason and Christopher L. Joannou and E. W. Odell and Vanya A. Gant and Robert Evans},
  journal={Infection and immunity},
  year={1998},
  volume={66 6},
  pages={2434-40}
}
Lactoferricin includes an 11-amino-acid amphipathic alpha-helical region which is exhibited on the outer surface of the amino-terminal lobe of lactoferrin. Synthetic peptides homologous to this region exhibited potent antibacterial activity against a selected range of both gram-negative and gram-positive bacteria. An analog synthesized with methionine substituted for proline at position 26, which is predicted to disrupt the helical region, abolished antibacterial activity against Escherichia… CONTINUE READING

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