Structure-function insights into the yeast Dam1 kinetochore complex.

  title={Structure-function insights into the yeast Dam1 kinetochore complex.},
  author={Eva Nogales and Vincent H. Ramey},
  journal={Journal of cell science},
  volume={122 Pt 21},
Faithful segregation of genetic material during cell division requires the dynamic but robust attachment of chromosomes to spindle microtubules during all stages of mitosis. This regulated attachment occurs at kinetochores, which are complex protein organelles that are essential for cell survival and genome integrity. In budding yeast, in which a single microtubule attaches per kinetochore, a heterodecamer known as the Dam1 complex (or DASH complex) is required for proper chromosome segregation… CONTINUE READING
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