Structure-function and biological role of betacellulin.

  title={Structure-function and biological role of betacellulin.},
  author={Andrew J Dunbar and Chris M Goddard},
  journal={The international journal of biochemistry & cell biology},
  volume={32 8},
Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. BTC was initially described, purified and cloned from a mouse insulinoma cell line. BTC is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. BTC binds and activates ErbB-1 and ErbB… CONTINUE READING

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