Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.

  title={Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.},
  author={Warner Phelps and Karl M{\"u}nger and Carole Lee Yee and Junor A. Barnes and Peter M Howley},
  journal={Journal of virology},
  volume={66 4},
The E7 gene of human papillomavirus type 16 encodes a multifunctional nuclear phosphoprotein that is functionally and structurally similar to the adenovirus (Ad) E1A proteins and the T antigens of other papovaviruses. E7 can cooperate with an activated ras oncogene to transform primary rodent cells, trans activate the Ad E2 promoter, and abrogate transforming growth factor beta-mediated repression of c-myc. Recent studies suggest that these functions may in part be a consequence of the ability… CONTINUE READING


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