Structure-function analysis of the bestrophin family of anion channels.

@article{Tsunenari2003StructurefunctionAO,
  title={Structure-function analysis of the bestrophin family of anion channels.},
  author={Takashi Tsunenari and Hui Sun and John P. Williams and Hugh B. Cahill and Philip M. Smallwood and King-Wai Yau and Jeremy Nathans},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 42},
  pages={
          41114-25
        }
}
The bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. The human genome codes for four bestrophins, each of which confers a distinctive plasma membrane conductance on transfected 293 cells. Extracellular treatment with methanethiosulfonate ethyltrimethylammonium (MTSET) of a series of substitution mutants that eliminate one or more cysteines from human bestrophin1 demonstrates that cysteine 69 is the single… CONTINUE READING

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