Structure-function analysis of the RNA helicase maleless


Loss of function of the RNA helicase maleless (MLE) in Drosophila melanogaster leads to male-specific lethality due to a failure of X chromosome dosage compensation. MLE is presumably involved in incorporating the non-coding roX RNA into the dosage compensation complex (DCC), which is an essential but poorly understood requirement for faithful targeting of… (More)


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@inproceedings{Izzo2008StructurefunctionAO, title={Structure-function analysis of the RNA helicase maleless}, author={Annalisa Izzo and Catherine Regnard and Violette Morales and Elisabeth Kremmer and Peter B. Becker}, booktitle={Nucleic acids research}, year={2008} }