Structure-function analysis of the RNA helicase maleless

  title={Structure-function analysis of the RNA helicase maleless},
  author={Annalisa Izzo and Catherine Regnard and Violette Morales and Elisabeth Kremmer and Peter B. Becker},
  booktitle={Nucleic acids research},
Loss of function of the RNA helicase maleless (MLE) in Drosophila melanogaster leads to male-specific lethality due to a failure of X chromosome dosage compensation. MLE is presumably involved in incorporating the non-coding roX RNA into the dosage compensation complex (DCC), which is an essential but poorly understood requirement for faithful targeting of the complex to the X chromosome. Sequence comparison predicts several RNA-binding domains in MLE but their properties have not been… CONTINUE READING
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