Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila.

@article{Parks2006StructurefunctionAO,
  title={Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila.},
  author={Annette L. Parks and Jane R. Stout and Scott B Shepard and Kristin M Klueg and Ana Alice Diniz dos Santos and Todd R Parody and Martina Va{\vs}kov{\'a} and Marc A. T. Muskavitch},
  journal={Genetics},
  year={2006},
  volume={174 4},
  pages={1947-61}
}
The transmembrane proteins Delta and Notch act as ligand and receptor in a conserved signaling pathway required for a variety of cell fate specification events in many organisms. Binding of Delta to Notch results in a proteolytic cascade that releases the Notch intracellular domain, allowing it to participate in transcriptional activation in the nucleus. Recent research has implicated the endocytic and ubiquitylation machinery as essential components of Delta-Notch signaling. Our analysis of… CONTINUE READING
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