Structure function analysis of benzalacetone synthase from Rheum palmatum.

  title={Structure function analysis of benzalacetone synthase from Rheum palmatum.},
  author={Tsuyoshi Abe and Hiroyuki Morita and Hisashi Noma and Toshiyuki Kohno and Hiroshi Noguchi and Ikuro Abe},
  journal={Bioorganic & medicinal chemistry letters},
  volume={17 11},
Benzalacetone synthase (BAS) is a plant-specific chalcone synthase (CHS) superfamily type III polyketide synthase (PKS) that catalyzes a one-step decarboxylative condensation of 4-coumaroyl-CoA with malonyl-CoA. The diketide forming activity of Rheum palmatum BAS is attributed to the characteristic substitution of the conserved active-site Phe215 with Leu (numbering in Medicago sativa CHS). To further understand the structure and function of R. palmatum BAS, four site-directed mutants (C197T… CONTINUE READING

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