Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human

  title={Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human},
  author={Benjamin Albert and Christine Colleran and Isabelle L{\'e}ger-Silvestre and Axel Bernhard Berger and Christophe Dez and Christophe Normand and Jorge Perez-Fernandez and Brian McStay and Olivier Gadal},
  journal={Nucleic Acids Research},
  pages={10135 - 10149}
Ribosome biogenesis is a major metabolic effort for growing cells. In Saccharomyces cerevisiae, Hmo1, an abundant high-mobility group box protein (HMGB) binds to the coding region of the RNA polymerase I transcribed ribosomal RNAs genes and the promoters of ∼70% of ribosomal protein genes. In this study, we have demonstrated the functional conservation of eukaryotic HMGB proteins involved in ribosomal DNA (rDNA) transcription. We have shown that when expressed in budding yeast, human UBF1 and a… 

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