Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human

@article{Albert2013StructurefunctionAO,
  title={Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human},
  author={B. Albert and Christine Colleran and I. L{\'e}ger-Silvestre and A. B. Berger and C. Dez and C. Normand and J. Pérez-Fernández and B. McStay and O. Gadal},
  journal={Nucleic Acids Research},
  year={2013},
  volume={41},
  pages={10135 - 10149}
}
Ribosome biogenesis is a major metabolic effort for growing cells. In Saccharomyces cerevisiae, Hmo1, an abundant high-mobility group box protein (HMGB) binds to the coding region of the RNA polymerase I transcribed ribosomal RNAs genes and the promoters of ∼70% of ribosomal protein genes. In this study, we have demonstrated the functional conservation of eukaryotic HMGB proteins involved in ribosomal DNA (rDNA) transcription. We have shown that when expressed in budding yeast, human UBF1 and a… Expand
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The high mobility group protein HMO1 functions as a linker histone in yeast
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Hmo1, an HMG‐box protein, belongs to the yeast ribosomal DNA transcription system
Hmo1 Is Required for TOR-Dependent Regulation of Ribosomal Protein Gene Transcription
An HMG Protein, Hmo1, Associates with Promoters of Many Ribosomal Protein Genes and throughout the rRNA Gene Locus in Saccharomyces cerevisiae
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