Structure elucidation of oxygenated lipids in human atherosclerotic lesions.

  title={Structure elucidation of oxygenated lipids in human atherosclerotic lesions.},
  author={Hartmut K{\"u}hn and Jutta Belkner and Rainer Wiesner and Tankred Schewe and Vadim Z. Lankin and Alla K. Tikhaze},
  volume={5 1},
Oxidative modification of low density lipoproteins and tissue lipids has been proposed to be involved in the pathogenesis of atherosclerosis. We examined human atherosclerotic lesions of various stages from fifteen victims of acute heart failure and detected substantial amounts of oxygenated fatty acids in the tissue ester lipids. The degree of lipid oxygenation correlated with the stage of advancement of the lesion. More than 85% of the oxygenated fatty acids were localized in the cholesterol… CONTINUE READING


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